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SupaClean
Multinational Pharmaceutical API Manufacturer
Recovery of Palladium on Carbon (Pd/C) Catalyst
Spain
Elimination of operator exposure to catalyst and solvents
Pharmaceutical
Low pressure catalytic hydrogenation is a common transformation process in the production of a wide variety of pharmaceutical compounds. The high activity of Palladium and Platinum means that catalysts based on these metals tend to be the most common. Processes include the production of products such as Vitamin A, Vitamin B2 Riboflavin, Cortisone, and Ephedrine, to name a few.
Once used in the synthesis, the catalyst needs to be removed for subsequent disposal or recycling. Traditional methods for recovering or capturing spent catalysts include, but are not limited to, manual plate filters, filter presses, bags or lenticulars.
The main problem with these technologies is potential operator exposure once the catalyst has been captured. So how do you capture the catalyst and remove it from the process while minimising or eliminating operator exposure?
This particular process used a Palladium on Carbon (Pd/C) catalyst (5 % wt. loading on an activated carbon matrix). This is supplied wet (50% water), then mixed with Methanol for use in the reaction vessel.
The customer traditionally used filter bags to capture the catalyst, but this method had inherent associated health and safety issues. Filter change outs increased the risk of operator exposure and made subsequent re-packaging for off-site processing complicated.
The customer introduced our SupaClean filter system to eliminate operator exposure and simplify the onward off-site reclamation of the valuable palladium.
Working closely with the customer resulted in the manufacture of a specially modified SupaClean filter, utilising 3 off 20" SupaSpun II filters in a 30" length SupaClean housing. The additional free volume available allowed up to 3 kg of concentrated catalyst slurry to be retained.
The vide below shows the retained catalyst being removed from the SupaClean housing.
The SupaClean system is extremely adaptable in terms of the filters used in the system and the material selection of the flexible bag. This means the customer can fully optimise the process while ensuring excellent chemical compatibility. All materials are FDA-approved, allowing seamless introduction into the pharmaceutical process.
For more detailed information on the product click here SupaClean.
We'll make sure you're getting the best out of your filtration system